Neuro Topics - Axon regeneration
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September 16, 2022
Yuqin Yin and Larry Benowitz describe a new study using RNA sequencing and bioinformatics to identify the transcription factor REST (a.k.a. NRSF) as a key repressor of the genetic program required for neurons to regenerate axons in the central nervous system. Counteracting the inhibitory effects of REST enhances the ability of retinal ganglion cells to regenerate axons through the injured optic nerve and of cortical neurons to regenerate axons in the corticospinal tract.
Original article in: Nature Communications >
July 22, 2022
Neurons called retinal ganglion cells (RGCs) send axons from the retina to the rest of the brain through the optic nerve. When the optic nerve is crushed, most RGCs die and few if any survivors regrow new axons. The labs of Josh Sanes (Harvard) and Zhigang He (Boston Children’s Hospital) recently published two papers defining gene expression programs that regulate RGC survival and regeneration.
Original article in: Neuron >
February 12, 2021
Yusuke Fukuda from the lab of Rosalind Segal shares new work identifying and exploring the function of an RNA-binding protein called SFPQ, which selectively binds to KIF5A--a kinesin motor protein in axons which is frequently mutated in Charcot-Marie-Tooth disorder and other neurodegenerative diseases.
Original article in: Journal of Cell Biology >
February 8, 2021
Harvard Gazette article recapping an online seminar about mental health during the pandemic. Experts from the Harvard T.H. Chan School of Public Health, the National Alliance on Mental Illness (NAMI), and the Dr. Lorna Breen Heroes’ Foundation gathered for an hour long online discussion of what may be one of the pandemic’s most painful if lesser-recognized effects.
Original article in: Journal of Cell Biology >
February 8, 2021
Round up of awards and honors earned by the HBI community
Original article in: Journal of Cell Biology >
September 8, 2020
Will Renthal & Ivan Tochitsky share recent work from Renthal & Woolf labs, suggesting that transcription factors induced early after peripheral nerve injury confer the cellular plasticity required for damaged sensory neurons to regenerate their axons
Original article in: Neuron >
July 1, 2020
A conversation with Lisa Goodrich, professor of neurobiology at HMS, in Harvard Medicine Magazine.
Original article in: Neuron >
July 1, 2020
Harvard Gazette article on new research from the labs of Paola Arlotta, Leonard Zon and Jeff Lichtman, first author James Harris, exploring how precise control over neuron growth might pave the way for repairing nervous system injuries.
Original article in: Developmental Cell >
February 28, 2019
Once seen as the nerve cells’ foot soldier, the axon emerges as an independent decision-maker in its own right.
Original article in: Nature >