Amar Sahay shares his lab’s discovery that many ultra-high confidence risk genes for autism, bipolar disorder, schizophrenia, and epilepsy may be regulators of experience-dependent plasticity of inhibitory neurons in the hippocampus of adult mice. Proof-of-concept experiments reveal that targeting one of these regulators can improve cognition and suppress seizures in a common mouse model of neurodevelopmental disorder risk.

Nuria Domínguez-Iturza and Paola Arlotta present new research describing the molecular signals that promote myelination in the cerebral cortex and show that these signals are expressed at varying levels across neuronal types. Their findings reveal how neuronal diversity shapes myelin development, providing new insights into brain development and disease.

In a first, a large, international team led by Rachel Wilson, Wei-Chung Allen Lee, Jan Drugoswitsch, Mala Murthy (Princeton) and colleagues, co-first authors Alexander S. Bates, Jasper S. Phelps, Minsu Kim, and Helen H. Yang, has published a complete wiring diagram of all the connections between neurons in the central nervous system of an adult fruit fly.