Neuro Topics - Human iPS cells
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January 21, 2022
HMS News article on new research from Isaac Chiu and colleagues, first author Nicole Yang, suggesting that anthrax has an unexpected benefit— one specific type of anthrax toxin can silence multiple types of pain in animals.
Original article in: Nature Neuroscience >
November 4, 2021
Valentina Lagomarsino shares new research from the lab of Dr. Tracy Young-Pearse. They generated induced pluripotent stem cell (iPSC) derived neurons from 53 deceased individuals and used them to identify specific proteins and pathways that are associated with an increased risk score for late onset Alzheimer's disease.
Original article in: Neuron >
November 2, 2021
Sarah Melzer from the Sabatini lab shares new work on the functions of the neuropeptide GRP in regulating fear memories. Their work highlights the mechanisms through which GRP modulates a specialized neuronal circuit in the cortex during fear conditioning.
Original article in: Cell >
Disease Characteristics of Dopaminergic Neurons in Neurodevelopmental and Neuropsychiatric Disorders
July 20, 2021
Maria Sundberg shares new research from the lab of Mustafa Sahin on the role of a small piece of chromosome 16, called the 16p11.2 locus, in disease phenotypes of dopaminergic neurons. The team identified that RhoA pathway activation led to network dysfunction in 16p11.2 deletion neurons. Its inhibitor, Rhosin, rescued the hyperactivity of these neuronal networks. In the future, the RhoA pathway and its inhibitors may serve as potential therapeutic targets.
Original article in: Nature Communications >
July 21, 2020
Jeffrey Schweitzer shares a new study demonstrating the advantages of the personalized cell therapy approach for Parkinson’s disease and potentially for other degenerative diseases of the nervous system.
Original article in: New England Journal of Medicine >
January 29, 2019
New cell model of most common form of Alzheimer’s points to molecular causes, drug target.
Original article in: Cell Reports >