Meng Zhang of the Zhuang lab describes new work using a single-cell transcriptome-imaging method, MERFISH, to generate a detailed cell map of the mouse primary motor cortex (MOp), revealing nearly 100 molecularly defined cell types and their spatial locations. Integrating MERFISH with retrograde tracing technique further allowed the team to understand how these different cell types connect with other brain regions.

Boston Children's Hospital Answers article highlighting the research of Annapurna Poduri and the Epilepsy Genetics team at Boston Children's Hospital.

Round up of awards and honors earned by the HBI community.

Neil Dani & Maria Lehtinen share new research done with Rebecca Herbst, Naomi Habib & Aviv Regev at the Broad Institute. Using single cell & nucleus sequencing, coupled with tissue-level mapping, they have generated the first cellular and spatial atlas of the choroid plexus blood-CSF barrier. This addresses a historical blind spot by characterizing the core cell types, subtypes, their spatial organization and diversity across brain regions of the developing, adult, and aging mouse brain.