Featured Story:
The Cell’s Protein Recycling Machine Has an Emergency Brake
October 29, 2026
Urte Venclovaite shares new research from the lab of John Hanna that provides a model for how two molecules involved in proteasome control, Blm10 and PI31, might work together to create a fail-safe system to keep the cell’s protein recycling system in check. This basic research on how protein control works in healthy cells might ultimately provide insights that advance our understanding of why protein control fails in conditions such as neurodegenerative disease.
Community Stories
October 21, 2026
How do brains fold? By combining MRI scans, soft gel experiments, computer simulations, physics and mathematics, researchers from the lab of L. Mahadevan studied brain development and mistakes therein, using data from ferrets, macaques, and humans. Their work shows that a simple physical mechanism—faster growth of the cortex relative to deeper tissue—can explain both normal brain folding across species and in some developmental brain disorders.
September 3, 2026
What if every cell in your brain had its own unique genome that permanently records its history, its sibling cells, its age, the effects of disease, and its struggle for survival? How would that change the way we think about aging and degeneration in the brain? Christopher Walsh discusses these questions in light of two new studies from his lab and collaborating groups.
September 2, 2026
Host-microbe interactions are essential for neurological function. Valentina Lagomarsino shares new research from the Rao Lab showing how microbes play a vital role in regulating the neuroendocrine axis and activity of motor circuits in the colon.
Original article in: Nature Neuroscience >
A Shared Mechanism for Cognitive Restoration and Seizure Suppression in Neurodevelopmental Disorders
August 25, 2026
Amar Sahay shares his lab’s discovery that many ultra-high confidence risk genes for autism, bipolar disorder, schizophrenia, and epilepsy may be regulators of experience-dependent plasticity of inhibitory neurons in the hippocampus of adult mice. Proof-of-concept experiments reveal that targeting one of these regulators can improve cognition and suppress seizures in a common mouse model of neurodevelopmental disorder risk.
Original article in: Nature >
In the News
October 28, 2026
George Church and colleagues, co-first authors Alexandru M. Plesa and Sascha Jung, have developed a new method for predicting tissue age and screening for genes that affect the aging process, offering a new way to search for genetic factors that could be manipulated to turn back the clock on aging cells and rejuvenate tissue.
Original article in: Nature Aging >
October 28, 2026
Amid the increasing prevalence of Alzheimer’s disease and related dementias (ADRD), Chirag Patel, Peng Gao, Chenshuang Li and colleagues have conducted what they describe as the most extensive systematic evaluation to date of associations between ADRD and nearly 200 environmental exposures — from pollution to diet to social connection.
Original article in: Alzheimer’s & Dementia >
October 28, 2026
Wade Regehr and colleagues have identified a wealth of new cell types that appear to work together in unexpected ways. By deepening understanding of the cerebellum’s structure and function, these findings could set the stage for developing new treatments for neurological disorders in which the cerebral cortex goes awry, including ataxia, depression, anxiety, sleep disorders, and cognitive or executive impairments.
Original article in: Neuron >
Awards & Honors
October 9, 2026
Round up of awards and honors earned by the HBI community.
September 15, 2026
Round up of awards and honors earned by the HBI community.