I currently lead the Cerebrovascular Aging and Spin Labeling (CASL) laboratory at MGH. I have a broad background in biomedical engineering and imaging physics, with specific training in magnetic resonance imaging (MRI) acquisition methods and processing approaches, their relevance to human vascular anatomy and physiology, and the translation of MRI methods for use in clinical studies across the human lifespan. A principal objective of my work has been the development of quantitative MRI approaches, including arterial spin labeling (ASL), for better characterizing cerebral hemodynamic and metabolic function. A central focus of my laboratory is on the application of these methods for studying hemo-metabolic precursors of tissue impairment due to cerebrovascular disease as well as response to disease-modifying therapies, including as part of longitudinal human trials. My current interests are in generalizing hemodynamic MRI approaches, including at 7 Tesla, to be broadly applicable for studying microvascular hemodynamic function in typical aging and in patients at risk for cerebrovascular diseases and dementia.