Massachusetts General Hospital News article on new research from the labs of Christiane Wrann, Rudolph Tanzi, and  Bruce Spiegelman, co-first authors Mohammad Islam and Sophia Valaris, demonstrating for the first time that irisin, the cleaved and circulating form of the exercise-induced membrane protein FNDC5, is sufficient to confer the benefits of exercise on cognitive function. This approach could potentially lead to a therapeutic for patients with Alzheimer’s disease and other neurodegenerative diseases.