Dr. Paola Arlotta, Professor of Stem Cell and Regenerative Biology, has been awarded the George Ledlie Prize by the President and Fellows of Harvard College.

Arlotta’s research focuses on the development of the mammalian brain, with the goal of figuring out the “molecular logic” that generates and maintains the amazing diversity of cell types found in the cerebral cortex. Her lab is also interested in understanding how problems in developmental processes can lead to neurological or psychiatric diseases. In addition to studying these topics in mouse embryos, the lab has recently developed “human brain organoids” – a new type of three dimensional in vitro model that aims to recapitulate in the laboratory dish some of the tissue architecture, cell type complexity and local connectivity found in real human brains.

“Still early in her career, Paola Arlotta has already had a profound impact on the world of developmental neurobiology,” said Harvard University Provost Alan Garber, as quoted in the Harvard Gazette. “Her groundbreaking discoveries have challenged received wisdom and directly contributed to new conceptual frameworks in the field.”

Arlotta, also quoted by the Harvard Gazette on receiving the award: “I am profoundly honored to have been selected to receive this prestigious award. I am very grateful to all the colleagues who have made my work possible, and have inspired me to dare in my path to discovery. This award is dedicated to my husband and children, for their enduring support and love every day.”

The George Ledlie Prize is given every two years to the Harvard scientist who “has by research, discovery, or otherwise made the most valuable contribution to science, or in any way for the benefit of mankind.”