HMS News article on new research from Joseph Arboleda-Velasquez, Yakeel Quiroz, and colleagues, co-first authors Francisco Lopera, Claudia Marino, Anita S. Chandrahas, Michael O’Hare, and Nelson David Villalba-Moreno. They studied the extraordinary case of a patient with strong genetic predisposition for early-onset Alzheimer’s disease who remained cognitively intact more than two decades beyond the expected age of memory impairment. This led to the discovery of a protective variant, a pathway for ‘resilience’ to dementia, and the identification of a brain region to target with therapies. Also featured in the Harvard Gazette.