New research from David Corey and colleagues, first author Maryna V Ivanchenko, delivered a corrected version of the faulty gene that causes Usher syndrome — PCDH15 — and was able to restore hearing in mouse models and also showed potential in retinal organoids and nonhuman primates for improving vision.

HMS News article on new research from David Corey, Artur A Indzhykulian, and colleagues, first author Maryna Ivanchenko. Using mice, the team designed a “mini gene” that could in the future be developed into a therapy for Usher Syndrome type 1F, a severe genetic condition that causes blindness and deafness.

Gwenaelle Geleoc shares her lab's new research into improving hearing and balance in mice. They targeted an Acadian human mutation in a gene essential for hearing and vision using local applications of antisense oligonucleotides.