Neuro Topics - Inflammation
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June 11, 2024
Using mouse and computer model experiments, researchers identified thousands of molecular interactions — most not previously known — between pain-initiating neurons, or nociceptors, and different types of immune cells. These interactions could help explain why pain hypersensitivity sometimes occurs during inflammation — and could also help researchers resolve it.
Original article in: Nature Immunology >
May 9, 2024
New research uncovers how inflammation damages excitatory synapses in an experimental model of MS. While there is a constant turnover of synapses in the healthy brain, inflammation accelerates this turnover so that synapses were gained and lost at higher rates. This widespread instability impacts the entire neuron and leading to important changes in the incoming inputs to individual neurons.
Original article in: Brain, Behavior, and Immunity >
April 22, 2024
Some infants who pass away from sudden infant death syndrome (SIDS) are known to have had acute minor infections. Could these have played a role in their death? Using next-generation molecular tools, a new study provides evidence that undiagnosed inflammation and occult infection can contribute to SIDS and the brainstem pathology seen in some infants.
Original article in: JAMA Neurology >