My research interests include brain imaging, genomics, early detection and preclinical biomarkers of Alzheimer’s disease and other dementias.

I’m the principal investigator of the Colombia-Boston (COLBOS) longitudinal biomarker study of autosomal-dominant Alzheimer’s disease, which follows individuals from the world’s largest extended family with a single, AD-causing mutation (E280A in Presenilin1). My research has focused on characterizing biological and physiological changes that may predispose individuals to develop memory loss or dementia later in life.