Presurgical brain mapping with multimodal neuroimaging techniques is critical for planning and conducting safe and effective brain surgeries –particularly when treating brain lesions close to regions that are important to our daily life, such as motor and language functional areas. Our lab focuses on improving presurgical brain mapping by developing and applying advanced image processing approaches for analyzing functional magnetic resonance imaging (fMRI) and diffusion MRI data. Using fMRI, we have developed easy-to-perform paradigms, such as resting-state and movie-watching fMRI, for the patients who cannot perform the conventional tasks due to neurological deficits. We are also interested in studying functional and structural brain connectivity to understand the neural mechanisms of neurological disorders, as well as treatment-induced cognitive impairments in patients. Our goals are to inform therapeutic development and improve patients’ overall well-being.