Mood and anxiety disorders are the most common psychiatric disorders in the United States. Standard treatments include psychotropic medications and psychotherapy, yet many individuals develop treatment-resistance; they are not able to benefit from standard interventions. Individuals with mood and anxiety disorders demonstrate differential brain network activity compared to individuals without these disorders. We use clinical neuroimaging such as magnetic resonance imaging (MRI) to identify brain targets and use brain stimulation methods such as low intensity focused ultrasound to change brain network activity and decrease psychiatric symptoms. Through this work, we aim to develop novel interventions for individuals with mood and anxiety disorders.