We use experimental approaches at the intersection of chemical biology, genetics and stem cell biology to investigate cellular pathways relevant to schizophrenia, bipolar disorder, autism and related neuropsychiatric disorders. A major focus of the lab involves the identification of cellular disease signatures using patient-derived neurons generated from induced pluripotent stem cells (iPSCs). We utilize complementary approaches in specific cellular subtypes and in three-dimensional cerebral organoids and brain assembloids generated from human iPSCs. We employ a range of methods including high-content imaging to investigate synaptic biology, multi-electrode arrays to examine neuronal function along with transcriptomic, proteomic and metabolomic experiments. We seek to develop new small molecules that can modulate disease-related processes in patient-derived neurons and develop new therapeutic approaches for targeting cognitive deficits in psychiatric disorders.