portrait of Paulo Lizano
Paulo Lizano, MD, PhD
Assistant Professor of Psychiatry, Harvard Medical School
Neuropsychiatrist, Beth Israel Deaconess Medical Center
Translational Predictors of Psychopathology and Disease Neurobiology

I chose to study the neurobiology of psychotic disorders given the lack of clinically tractable diagnostic biomarkers, as well as an absence of disease modifying treatments. Thus, my goal is to create a research program that integrates translational predictors of psychopathology and disease neurobiology in a clinically relevant manner. My research focuses on utilizing retinal imaging, neuroimaging, blood-based biomarker technology, and neuromodulation to better characterize and offer potential interventions in serious mental illness, specifically idiopathic psychotic disorders. I actively develop retinal and brain imaging processing tools and blood-based biosignatures. My work also involves in vivo and ex vivo techniques to examine inflammation-mediated disruption of the blood brain barrier in psychosis. I have also extended my work to use non-invasive neuromodulation to target causal brain regions in the extrastriate visual cortex or superior temporal sulcus that are associated with visual hallucinations and overall hallucinations respectively. I am also in the process of starting up a first episode psychosis clinic of which I will be directing.