Much of the last 50 years of biology can be summarized as a search for the connection between the genotype and the phenotype. The more complex the phenotype, the more interesting and difficult the task is; hence the challenges of studying human behavior, aging, and systemic disease. That we could build our understanding from piecing together the microscopic molecular details seems today to be a vain hope. My lab is dedicated to one elusive systemic problem on the cellular level and that is the control of cell size, which implies a poorly understood correlation with the rate of growth with the rate of division. We also study at the molecular level cell and organ size regulation and the Hippo pathway and cell motility and the Wnt pathway. On a larger level we hope to understand the circuits involved the pathways of cell differentiation in the embryo by coupling proteomics and single cell transcriptomics, which yield accurate molecular information with new approaches of reverse engineering and deep learning. Finally, comparative aspects of development and genomics can give us new insights into how organisms change in evolution and illuminate on a mechanistic level the principles of evolvability.