The Functional Neuroimaging lab focuses on the development and application of new neuroimaging techniques to localize and characterize brain circuitry dysfunction underlying major psychiatric disorders. We have developed novel methods, paradigms and analytics for both PET and MRI imaging, and have identified neural circuitry abnormalities associated with a number of major psychiatric disorders. Particular areas of focus are the characterization of frontal-limbic modulation abnormalities across the neuropsychiatric spectrum, and the identification of final common neural pathways underlying psychiatric clinical phenotypes. We have also made contributions to neural circuit models of depression, PTSD, and borderline personality disorder. The aim of our systems-level neuropathophysiology work is to help provide a foundation for the development of novel, targeted, biologically-based diagnostic and therapeutic strategies to aid those suffering with mental illness.