Bradley Hyman
Bradley Hyman, MD, PhD
John B. Penney, Jr. Professor of Neurology, Harvard Medical School
Alzheimer’s Unit Director, Institute for Neurodegenerative Disease, Massachusetts General Hospital
Director, Massachusetts Alzheimer’s Disease Research Center
Anatomical and Molecular Basis of Dementia

Our lab studies the anatomical and molecular basis of dementia in Alzheimer’s disease and dementia with Lewy bodies. Approaches focus on transgenic mouse models and human neuropathological samples, using advanced microscopy techniques for in vivo longitudinal imaging, direct imaging on neuropathological processes including cell death, and functional imaging including in vivo assessment of calcium reporters. Quantitative approaches have been developed to apply to clinical pathological and genotype/phenotype analyses. Recent studies have developed the use of multiphoton microscopy for in vivo anatomical and functional imaging in transgenic mouse models of Alzheimer’s disease and the utilization of gene transfer techniques to introduce potentially disease-modifying genes into specific cortical regions. We have also developed fluorescence resonance energy transfer (FRET) approaches to allow observation of protein-protein interactions with subcellular resolution, both in vitro and in vivo. These techniques are utilized to examine the alterations that occur in Alzheimer’s disease brain, and in mouse models expressing genetic mutants that are linked to Alzheimer’s disease.