Currently, I am a Postdoctoral Fellow in Amar Sahay´s lab. I am a trained in vivo electrophysiologist and dared to join a rather molecular lab at Massachusetts General Hospital/ Harvard Medical School to learn the joy of circuit hacking.
I have been performing in vivo imaging as well as in vivo electrophysiology in combination with molecular manipulation of hippocampal circuits to gain more knowledge about neuronal dynamics in learning and memory consolidation. My main focus is hereby the balance of excitation & inhibition (E/I balance) in the hippocampus-cortical network as it is an early alteration in many cognitive disorders such as Alzheimer’s disease or Autism.
Our first study from recordings in hippocampus & ACC is currently under revision at eLife and can be found on BioRxiv. Ongoing experiments focus on E/I balance in a recently published knock-in model of Amyloidosis similar to that seen in Alzheimer’s disease. Here, I combine the above described approaches to test if 1) we can restore E/I balance in the hippocampus of KI mice and 2) if that rescues neuronal dynamics during learning and memory consolidation.
Together with HBI I started a slack channel to bring together the calcium imaging people of Harvard & affiliated Hospitals and am delighted to see a new networking resource!