The mission of our lab is to dissect fundamental mechanisms of cellular homeostasis with a focus on membrane proteins which account for a third of the human proteome and mediate functions essential for the survival of all organisms, from bacteria to humans.

Our curiosity-driven investigations are founded on the premise that pathogenic mutations disrupt key cellular processes, and reveal pathways central to human physiology and disease. Specifically we focus on pathways involving membrane proteins that are disrupted in genetically-defined kidney, metabolic and neurodegenerative diseases.