Chronobiology & The Brain

Jonathan Lipton, MD, PhD
Principal Investigator, FM Kirby Neurobiology Center, Boston Children’s Hospital; Assistant Professor of Neurology at Harvard Medical School. Contact Dr Lipton.

Group Co-Founders & Co-Coordinators:  Rajindra (Raj) Aryal, PhD, and Alfred Tamayo, PhD



Speaker I
Speaker II
 Robert Thomas, BIDMC
Jonathan Lipton, BCH
Beth Klerman, BWH
Charles Weitz, HMS
Steve Reppert, UMASS
Kun Hu, BWH
Michael Rosbash, Brandeis
Frank Scheer, BWH
Harry Pantazopoulos, McLean
Ryan Fame, BCH Pathology
Feng Feng Bei. BWH
Takao Hensch, BCH


Clock in brain

The circadian clock is the fundamental timing mechanism that links organismal function to the oscillations of the planet. Chronobiology is multidisciplinary and bridges across ontogeny, neuroscience, and metabolism with potentially broad implications for animal behavior, cellular function and human health. Indeed, disruption of circadian timing has been linked to psychiatric, neurologic, metabolic and neoplastic diseases in both humans and animal models. A deeper understanding of the physiological, theoretical, cellular, and translational underpinnings of circadian timing holds enormous therapeutic promise. Our goal in this Affinity Group is to provide a secure, relaxed, yet rigorous forum in which investigators and trainees from across the Boston research community can cross-pollinate expertise, ideas, and collaborations.

We hope to bring together PI’s and trainees working on diverse aspects of Chronobiology (from theoretical to translational) across the Boston academic community to have a chance to meet and discuss ongoing research and issues in the field in a collaborative setting. We are aiming to meet one evening every two months or so over the academic year.

We will sponsor 4-6 interactive dinner seminars per year. Each meeting will feature two research presentations highlighting works-in-progress or nascent projects, and/or a timely review of an important topic in chronobiology. There will be abundant time for lively discussion. We ask that principal investigators interested in participating commit to personally attending at least 4 of the year’s events. Participation implies collegiality and confidentiality.

"Unexpected Increase in Melatonin Concentrations during Daytime Sleep in Simulated Night Work Protocol”
Jingyi Qian, PhD, Division of Sleep Medicine, Harvard Medical School, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Group of Dr. Frank Scheer

"Temporal and genetic analysis of molecular complexes of the mammalian circadian clock"
Rajindra (Raj) Aryal, PhD, Weitz lab, Department of Neurobiology, Harvard Medical School